Archives of Pediatric Infectious Diseases

Published by: Kowsar

Red Cell Distribution Width Elevation and Sepsis in Pediatric Critically Ill Patients

Ghamartaj Khanbabaee 1 , Seyedeh Masumeh Hashemi 2 , Sara Salarian 3 , Mohammad Reza Fariborzi 4 and Azadeh Kiumarsi 5 , *
Authors Information
1 Department of Pediatric Respiratory Diseases, CF Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Pediatric Pathology Research Center, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Anesthesiology Research Center, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
4 Department of Pediatric Gastroentrology, Boushehr Medical University, Boushehr, IR Iran
5 Department of Pediatric Hematology, St Aliasghar Hospital, Iran Medical University, Tehran, IR Iran
Article information
  • Archives of Pediatric Infectious Diseases: April 2018, 6 (2); e12210
  • Published Online: March 11, 2018
  • Article Type: Research Article
  • Received: April 27, 2017
  • Revised: September 23, 2017
  • Accepted: November 12, 2017
  • DOI: 10.5812/pedinfect.12210

To Cite: Khanbabaee G, Hashemi S M, Salarian S, Fariborzi M R, Kiumarsi A. Red Cell Distribution Width Elevation and Sepsis in Pediatric Critically Ill Patients, Arch Pediatr Infect Dis. 2018 ; 6(2):e12210. doi: 10.5812/pedinfect.12210.

Copyright © 2018, Archives of Pediatric Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Pomerantz WJ, Weiss SL, Kaplan SL, Randolph AG. Systemic inflammatory response syndrome (SIRS) and sepsis in children: Definitions, epidemiology, clinical manifestations, and diagnosis. UpToDate, Waltham; 2015.
  • 2. Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trzeciak S, et al. Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med. 2006;48(1):28-54. doi: 10.1016/j.annemergmed.2006.02.015. [PubMed: 16781920].
  • 3. Matot I, Sprung CL. Definition of sepsis. Intensive Care Med. 2001;27 Suppl 1:S3-9. [PubMed: 11307368].
  • 4. Arslan Z, Ozmen O, Karakoc F, Karaca M, Aktas M. Factors Affecting Prognosis in Sepsis Patients Admitted to Intensive Care Unit. 2015.
  • 5. Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, et al. Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med. 2002;28(2):108-21. doi: 10.1007/s00134-001-1143-z. [PubMed: 11907653].
  • 6. Dupuy AM, Philippart F, Pean Y, Lasocki S, Charles PE, Chalumeau M, et al. Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections. Ann Intensive Care. 2013;3(1):22. doi: 10.1186/2110-5820-3-22. [PubMed: 23837559].
  • 7. Bozza FA, Bozza PT, Castro Faria Neto HC. Beyond sepsis pathophysiology with cytokines: what is their value as biomarkers for disease severity?. Mem Inst Oswaldo Cruz. 2005;100 Suppl 1:217-21. [PubMed: 15962126].
  • 8. Chiari MM, Bagnoli R, De Luca PD, Monti M, Rampoldi E, Cunietti E. Influence of acute inflammation on iron and nutritional status indexes in older inpatients. J Am Geriatr Soc. 1995;43(7):767-71. [PubMed: 7602028].
  • 9. Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion. 2005;20(2):83-90. doi: 10.1191/0267659105pf793oa. [PubMed: 15918445].
  • 10. Al-Najjar Y, Goode KM, Zhang J, Cleland JG, Clark AL. Red cell distribution width: an inexpensive and powerful prognostic marker in heart failure. Eur J Heart Fail. 2009;11(12):1155-62. doi: 10.1093/eurjhf/hfp147. [PubMed: 19926599].
  • 11. Bazick HS, Chang D, Mahadevappa K, Gibbons FK, Christopher KB. Red cell distribution width and all-cause mortality in critically ill patients. Crit Care Med. 2011;39(8):1913-21. doi: 10.1097/CCM.0b013e31821b85c6. [PubMed: 21532476].
  • 12. Goldstein B, Giroir B, Randolph A, International Consensus Conference on Pediatric S. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2-8. doi: 10.1097/01.PCC.0000149131.72248.E6. [PubMed: 15636651].
  • 13. Bone RC. Important new findings in sepsis. JAMA. 1997;278(3):249. [PubMed: 9218676].
  • 14. Raghavan M, Marik PE. Management of sepsis during the early "golden hours". J Emerg Med. 2006;31(2):185-99. [PubMed: 17044583].
  • 15. Sonmezer MC, Tulek N. Biomarkers in Bacterial Infections and Sepsis. Klimik J. 2015;28(3):96-102. doi: 10.5152/kd.2015.20.
  • 16. Meisner M. Biomarkers of sepsis: clinically useful?. Curr Opin Crit Care. 2005;11(5):473-80. [PubMed: 16175035].
  • 17. Wang F, Pan W, Pan S, Ge J, Wang S, Chen M. Red cell distribution width as a novel predictor of mortality in ICU patients. Ann Med. 2011;43(1):40-6. doi: 10.3109/07853890.2010.521766. [PubMed: 20961272].
  • 18. Jo YH, Kim K, Lee JH, Kang C, Kim T, Park HM, et al. Red cell distribution width is a prognostic factor in severe sepsis and septic shock. Am J Emerg Med. 2013;31(3):545-8. doi: 10.1016/j.ajem.2012.10.017. [PubMed: 23380094].
  • 19. Kim CH, Park JT, Kim EJ, Han JH, Han JS, Choi JY, et al. An increase in red blood cell distribution width from baseline predicts mortality in patients with severe sepsis or septic shock. Crit Care. 2013;17(6):R282. doi: 10.1186/cc13145. [PubMed: 24321201].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments