Archives of Pediatric Infectious Diseases

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Prevalence and Severity of Thrombocytopenia in Blood Culture Proven Neonatal Sepsis: A Prospective Study

Ramesh Bhat Y. 1 , * , Phalguna Kousika 1 , Leslie Lewis 1 and Jayashree Purkayastha 1
Authors Information
1 Department of Pediatrics, Kasturba Medical College, Manipal University, Manipal-576104, Karnataka, India
Article information
  • Archives of Pediatric Infectious Diseases: April 2018, 6 (2); e12471
  • Published Online: March 18, 2018
  • Article Type: Research Article
  • Received: March 18, 2017
  • Revised: July 3, 2017
  • Accepted: August 19, 2017
  • DOI: 10.5812/pedinfect.12471

To Cite: Bhat Y. R, Kousika P, Lewis L, Purkayastha J. Prevalence and Severity of Thrombocytopenia in Blood Culture Proven Neonatal Sepsis: A Prospective Study, Arch Pediatr Infect Dis. 2018 ; 6(2):e12471. doi: 10.5812/pedinfect.12471.

Abstract
Copyright © 2018, Archives of Pediatric Infectious Diseases. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
6. Conclusions
Acknowledgements
Footnote
References
  • 1. Roberts I, Murray NA. Neonatal thrombocytopenia: causes and management. Arch Dis Child Fetal Neonatal Ed. 2003;88(5):F359-64. [PubMed: 12937037].
  • 2. Khassawneh M, Khader Y, Abuqtaish N. Clinical features of neonatal sepsis caused by resistant Gram-negative bacteria. Pediatr Int. 2009;51(3):332-6. doi: 10.1111/j.1442-200X.2008.02767.x. [PubMed: 19400829].
  • 3. Bhat MA, Bhat JI, Kawoosa MS, Ahmad SM, Ali SW. Organism-specific platelet response and factors affecting survival in thrombocytopenic very low birth weight babies with sepsis. J Perinatol. 2009;29(10):702-8. doi: 10.1038/jp.2009.72. [PubMed: 19554015].
  • 4. Guida JD, Kunig AM, Leef KH, McKenzie SE, Paul DA. Platelet count and sepsis in very low birth weight neonates: is there an organism-specific response?. Pediatrics. 2003;111(6 Pt 1):1411-5. [PubMed: 12777561].
  • 5. Charoo BA, Iqbal JI, Iqbal Q, Mushtaq S, Bhat AW, Nawaz I. Nosocomial sepsis-induced late onset thrombocytopenia in a neonatal tertiary care unit: a prospective study. Hematol Oncol Stem Cell Ther. 2009;2(2):349-53. [PubMed: 20118059].
  • 6. Torkaman M, Afsharpaiman SH, Hoseini MJ, Moradi M, Mazraati A, Amirsalari S, et al. Platelet count and neonatal sepsis: a high prevalence of Enterobacter spp. Singapore Med J. 2009;50(5):482-5. [PubMed: 19495516].
  • 7. Torres Claveras S, Dupla Arenaz M, Perez Delgado R, Aliaga Mazas Y, Rebage Moises V. [Nosocomial Candida infections and thrombocytopenia in very low birth weight newborns]. An Pediatr (Barc). 2007;67(6):544-7. [PubMed: 18053518].
  • 8. Bonifacio L, Petrova A, Nanjundaswamy S, Mehta R. Thrombocytopenia related neonatal outcome in preterms. Indian J Pediatr. 2007;74(3):269-74. [PubMed: 17401266].
  • 9. Roberts I, Stanworth S, Murray NA. Thrombocytopenia in the neonate. Blood Rev. 2008;22(4):173-86. doi: 10.1016/j.blre.2008.03.004. [PubMed: 18433954].
  • 10. Murray NA, Howarth LJ, McCloy MP, Letsky EA, Roberts IA. Platelet transfusion in the management of severe thrombocytopenia in neonatal intensive care unit patients. Transfus Med. 2002;12(1):35-41. [PubMed: 11967135].
  • 11. Arif SH, Ahmad I, Ali SM, Khan HM. Thrombocytopenia and bacterial sepsis in neonates. Indian J Hematol Blood Transfus. 2012;28(3):147-51. doi: 10.1007/s12288-011-0118-7. [PubMed: 23997450].
  • 12. Roberts IA, Murray NA. Neonatal thrombocytopenia: new insights into pathogenesis and implications for clinical management. Curr Opin Pediatr. 2001;13(1):16-21. [PubMed: 11176238].
  • 13. Colarizi P, Fiorucci P, Caradonna A, Ficuccilli F, Mancuso M, Papoff P. Circulating thrombopoietin levels in neonates with infection. Acta Paediatr. 1999;88(3):332-7. [PubMed: 10229048].
  • 14. Ahmad MS, Waheed A. Platelet counts, MPV and PDW in culture proven and probable neonatal sepsis and association of platelet counts with mortality rate. J Coll Physicians Surg Pak. 2014;24(5):340-4. [PubMed: 24848393].
  • 15. Levit O, Bhandari V, Li FY, Shabanova V, Gallagher PG, Bizzarro MJ. Clinical and laboratory factors that predict death in very low birth weight infants presenting with late-onset sepsis. Pediatr Infect Dis J. 2014;33(2):143-6. doi: 10.1097/INF.0000000000000024. [PubMed: 24418836].
  • 16. Brown RE, Rimsza LM, Pastos K, Young L, Saxonhouse MA, Bailey M, et al. Effects of sepsis on neonatal thrombopoiesis. Pediatr Res. 2008;64(4):399-404. doi: 10.1203/PDR.0b013e318181ad49. [PubMed: 18552713].
  • 17. Muley VA, Ghadage DP, Bhore AV. Bacteriological Profile of Neonatal Septicemia in a Tertiary Care Hospital from Western India. J Glob Infect Dis. 2015;7(2):75-7. doi: 10.4103/0974-777X.154444. [PubMed: 26069427].
  • 18. Zaidi AK, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldmann DA. Hospital-acquired neonatal infections in developing countries. Lancet. 2005;365(9465):1175-88. doi: 10.1016/S0140-6736(05)71881-X. [PubMed: 15794973].
  • 19. Bhat YR, Lewis LE, K EV. Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India. Ital J Pediatr. 2011;37:32. doi: 10.1186/1824-7288-37-32. [PubMed: 21745376].
  • 20. Manzoni P. Hematologic Aspects of Early and Late-Onset Sepsis in Preterm Infants. Clin Perinatol. 2015;42(3):587-95. doi: 10.1016/j.clp.2015.04.012. [PubMed: 26250919].
  • 21. Sheu JR, Hung WC, Wu CH, Ma MC, Kan YC, Lin CH, et al. Reduction in lipopolysaccharide-induced thrombocytopenia by triflavin in a rat model of septicemia. Circulation. 1999;99(23):3056-62. [PubMed: 10368125].
  • 22. Sola MC, Calhoun DA, Hutson AD, Christensen RD. Plasma thrombopoietin concentrations in thrombocytopenic and non-thrombocytopenic patients in a neonatal intensive care unit. Br J Haematol. 1999;104(1):90-2. [PubMed: 10027717].
  • 23. Chen HN, Lee ML, Yu WK, Lin YW, Tsao LY. Late-onset Enterobacter cloacae sepsis in very-low-birth-weight neonates: experience in a medical center. Pediatr Neonatol. 2009;50(1):3-7. doi: 10.1016/S1875-9572(09)60022-X. [PubMed: 19326831].
  • 24. Khashu M, Osiovich H, Henry D, Al Khotani A, Solimano A, Speert DP. Persistent bacteremia and severe thrombocytopenia caused by coagulase-negative Staphylococcus in a neonatal intensive care unit. Pediatrics. 2006;117(2):340-8. doi: 10.1542/peds.2005-0333. [PubMed: 16452352].
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