Archives of Pediatric Infectious Diseases

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Comparison of High Loading Dose Versus Usual Dose of Rectal Acetaminophen in the Treatment of Febrile Children

Houman Hashemian 1 , * , Mohammad Momtazbakhsh 1 and Zahra Atrkar
Authors Information
1 Department of Pediatrics, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, IR Iran
Article information
  • Archives of Pediatric Infectious Diseases: October 01, 2013, 1 (3); 126-30
  • Published Online: October 29, 2013
  • Article Type: Research Article
  • Received: January 19, 2013
  • Revised: January 29, 2013
  • Accepted: April 8, 2013
  • DOI: 10.5812/pedinfect.10350

To Cite: Hashemian H, Momtazbakhsh M, Atrkar Z. Comparison of High Loading Dose Versus Usual Dose of Rectal Acetaminophen in the Treatment of Febrile Children, Arch Pediatr Infect Dis. 2013 ; 1(3):126-30. doi: 10.5812/pedinfect.10350.

Copyright © 2013, Pediartric Infections Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Nield LS, Kamat D. Nelson Textbook of Pediatrics. 2011;
  • 2. Treluyer JM, Tonnelier S, d'Athis P, Leclerc B, Jolivet-Landreau I, Pons G. Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose. Pediatrics. 2001; 108(4)[PubMed]
  • 3. Ward MA, Parcells CL. Textbook of Pediatrics Infectious Disease. 2009; : 105-10
  • 4. Amdekar YK. Rational use of antipyretics. Indian Pediatr. 2003; 40(6): 541-4[PubMed]
  • 5. Auria JP. Primary Health Care of Infants, Children & Adolescents. 2002; : 704-5
  • 6. Russell FM, Shann F, Curtis N, Mulholland K. Evidence on the use of paracetamol in febrile children. Bull World Health Organ. 2003; 81(5): 367-72[PubMed]
  • 7. Scolnik D, Kozer E, Jacobson S, Diamond S, Young NL. Comparison of oral versus normal and high-dose rectal acetaminophen in the treatment of febrile children. Pediatrics. 2002; 110(3): 553-6[PubMed]
  • 8. Brown RD, Wilson JT, Kearns GL, Eichler VF, Johnson VA, Bertrand KM. Single-dose pharmacokinetics of ibuprofen and acetaminophen in febrile children. J Clin Pharmacol. 1992; 32(3): 231-41[PubMed]
  • 9. Roberts LJ, Morrow JM. Goodman & Gilman's the pharmacological basis of therapeutics. 2002; : 703-4
  • 10. Birmingham PK, Tobin MJ, Henthorn TK, Fisher DM, Berkelhamer MC, Smith FA, et al. Twenty-four-hour pharmacokinetics of rectal acetaminophen in children: an old drug with new recommendations. Anesthesiology. 1997; 87(2): 244-52[PubMed]
  • 11. Hahn TW, Henneberg SW, Holm-Knudsen RJ, Eriksen K, Rasmussen SN, Rasmussen M. Pharmacokinetics of rectal paracetamol after repeated dosing in children. Br J Anaesth. 2000; 85(4): 512-9[PubMed]
  • 12. van der Marel CD, van Lingen RA, Pluim MA, Scoones G, van Dijk M, Vaandrager JM, et al. Analgesic efficacy of rectal versus oral acetaminophen in children after major craniofacial surgery. Clin Pharmacol Ther. 2001; 70(1): 82-90[DOI][PubMed]
  • 13. Birmingham PK, Tobin MJ, Fisher DM, Henthorn TK, Hall SC, Cote CJ. Initial and subsequent dosing of rectal acetaminophen in children: a 24-hour pharmacokinetic study of new dose recommendations. Anesthesiology. 2001; 94(3): 385-9[PubMed]
  • 14. Montgomery CJ, McCormack JP, Reichert CC, Marsland CP. Plasma concentrations after high-dose (45 rectal acetaminophen in children. Can J Anaesth. 1995; 42(11): 982-6[DOI][PubMed]
  • 15. Lee CKK, Tschudy MM, Arcara K. The Harriet Lane Handbook. 2012; : 682-3
  • 16. Sweetman SC. 2009; : 108-11
  • 17. Howell TK, Patel D. Plasma paracetamol concentrations after different doses of rectal paracetamol in older children A comparison of 1 g vs. 40 mg x kg(-1). Anaesthesia. 2003; 58(1): 69-73[PubMed]
  • 18. Beck DH, Schenk MR, Hagemann K, Doepfmer UR, Kox WJ. The pharmacokinetics and analgesic efficacy of larger dose rectal acetaminophen (40 mg/kg) in adults: a double-blinded, randomized study. Anesth Analg. 2000; 90(2): 431-6[PubMed]
  • 19. Golestan M, Karbasi SA, Bafghi MS, et al . Comparsion of oral acetaminophen with different doses in febrile children. Iran J Pediatr. 2005; 15(4): 373-8
  • 20. Blaisdell J, Mohrenweiser H, Jackson J, Ferguson S, Coulter S, Chanas B, et al. Identification and functional characterization of new potentially defective alleles of human CYP2C19. Pharmacogenetics. 2002; 12(9): 703-11[PubMed]
  • 21. Nabulsi M, Tamim H, Sabra R, Mahfoud Z, Malaeb S, Fakih H, et al. Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial [ISRCTN11886401]. BMC Pediatr. 2005; 5: 35[DOI][PubMed]
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