Archives of Pediatric Infectious Diseases

Published by: Kowsar

Prophylactic Probiotics for Prevention of Necrotizing Enterocolitis (NEC) in Low Birth Weight Neonates; Quality of the Evidence

Mario Augusto Rojas 1 , *
Author Information
1 Wake Forest University School of Medicine, Winston-Salem, USA
Article information
  • Archives of Pediatric Infectious Diseases: April 01, 2014, 2 (2); 231-232
  • Published Online: April 14, 2014
  • Article Type: Letter
  • Received: October 8, 2013
  • Accepted: October 11, 2013
  • DOI: 10.5812/pedinfect.15320

To Cite: Rojas M A. Prophylactic Probiotics for Prevention of Necrotizing Enterocolitis (NEC) in Low Birth Weight Neonates; Quality of the Evidence, Arch Pediatr Infect Dis. 2014 ; 2(2):231-232. doi: 10.5812/pedinfect.15320.

Copyright © 2014, Pediartric Infections Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. Barclay AR, Stenson B, Simpson JH, Weaver LT, Wilson DC. Probiotics for necrotizing enterocolitis: a systematic review. J Pediatr Gastroenterol Nutr. 2007; 45(5): 569-76[DOI][PubMed]
  • 2. Deshpande G, Rao S, Patole S, Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics. 2010; 125(5): 921-30[DOI][PubMed]
  • 3. Alfaleh K, Anabrees J, Bassler D, Al-Kharfi T. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev. 2011; (3)[DOI][PubMed]
  • 4. Wang Q, Dong J, Zhu Y. Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials. J Pediatr Surg. 2012; 47(1): 241-8[DOI][PubMed]
  • 5. Bernardo WM, Aires FT, Carneiro RM, Sa FP, Rullo VE, Burns DA. Effectiveness of probiotics in the prophylaxis of necrotizing enterocolitis in preterm neonates: a systematic review and meta-analysis. J Pediatr (Rio J). 2013; 89(1): 18-24[DOI][PubMed]
  • 6. Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants. A prospective double-blind study. Biol Neonate. 2002; 82(2): 103-8[PubMed]
  • 7. Lin HC, Hsu CH, Chen HL, Chung MY, Hsu JF, Lien RI, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics. 2008; 122(4): 693-700[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments