Archives of Pediatric Infectious Diseases

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Detection of Metallo-β-Lactamases and Klebsiella pneumonia Carbapenemases in Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

Maryam Tarhani 1 , Mojdeh Hakemi-Vala 1 , * , Ali Hashemi 1 , Jamileh Nowroozi 2 and Ghamartaj Khanbababee 3
Authors Information
1 Department of Microbiology, Medical School, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, IR Iran
2 Department of Microbiology, North Branch, Islamic Azad University, Tehran, IR Iran
3 Department of Pediatric Respiratory Diseases, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, IR Iran
Article information
  • Archives of Pediatric Infectious Diseases: July 01, 2016, 4 (3); e35905
  • Published Online: June 18, 2016
  • Article Type: Research Article
  • Received: January 19, 2016
  • Revised: April 25, 2016
  • Accepted: May 5, 2016
  • DOI: 10.5812/pedinfect.35905

To Cite: Tarhani M, Hakemi-Vala M, Hashemi A, Nowroozi J, Khanbababee G. Detection of Metallo-β-Lactamases and Klebsiella pneumonia Carbapenemases in Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients, Arch Pediatr Infect Dis. 2016 ; 4(3):e35905. doi: 10.5812/pedinfect.35905.

Copyright © 2016, Pediartric Infections Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Agarwal G, Kapil A, Kabra SK, Das BK, Dwivedi SN. Characterization of Pseudomonas aeruginosa isolated from chronically infected children with cystic fibrosis in India. BMC Microbiol. 2005; 5: 43[DOI][PubMed]
  • 2. Kanj SS, Kanafani ZA. Current concepts in antimicrobial therapy against resistant gram-negative organisms: extended-spectrum beta-lactamase-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae, and multidrug-resistant Pseudomonas aeruginosa. Mayo Clin Proc. 2011; 86(3): 250-9[DOI][PubMed]
  • 3. Shahcheraghi F, Nikbin VS, Feizabadi MM. Prevalence of ESBLs genes among multidrug-resistant isolates of Pseudomonas aeruginosa isolated from patients in Tehran. Microb Drug Resist. 2009; 15(1): 37-9[DOI][PubMed]
  • 4. Fallah F, Borhan RS, Hashemi A. Detection of bla(IMP) and bla(VIM) metallo-beta-lactamases genes among Pseudomonas aeruginosa strains. Int J Burns Trauma. 2013; 3(2): 122-4[PubMed]
  • 5. Performance standards for antimicrobial susceptibility testing; Twenty-second informational supplement. 2012;
  • 6. Roodsari MR, Fallah F, Taherpour A, Vala M, Hashemi A. Carbapenem-resistant bacteria and laboratory detection methods. Arch Pediatr Infect Dis. 2014; 2(1): 188-91
  • 7. Ma L, Chang FY, Fung CP, Chen TL, Lin JC, Lu PL, et al. Variety of TEM-, SHV-, and CTX-M-type beta-lactamases present in recent clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae from Taiwan. Microb Drug Resist. 2005; 11(1): 31-9[DOI][PubMed]
  • 8. Poirel L, Walsh TR, Cuvillier V, Nordmann P. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis. 2011; 70(1): 119-23[DOI][PubMed]
  • 9. Paixao VA, Barros TF, Mota CM, Moreira TF, Santana MA, Reis JN. Prevalence and antimicrobial susceptibility of respiratory pathogens in patients with cystic fibrosis. Braz J Infect Dis. 2010; 14(4): 406-9[PubMed]
  • 10. Forozsh FM, Irajian G, Moslehi TZ, Fazeli H, Salehi M, Rezania S. Drug resistance pattern of Pseudomonas aeruginosa strains isolated from cystic fibrosis patients at Isfahan AL Zahra hospital, Iran (2009-2010). Iran J Microbiol. 2012; 4(2): 94-7[PubMed]
  • 11. Bagheri Bejestani F, Hakemi-Vala M, Momtaheni R, Bagheri Bejestani O, Gholami M. The Frequency of imp and vim Genes Among Pseudomonas aeruginosa Isolates From Children’s Medical Center of Tehran. Arch Clin Infect Dis. 2015; 10(1)
  • 12. Aktas Z, Satana D, Kayacan C, Can B, Gonullu N, Kucukbasmaci O. [Antibiotic susceptibility rates and beta-lactam resistance mechanisms of Pseudomonas aeruginosa strains]. Mikrobiyol Bul. 2012; 46(3): 386-97[PubMed]
  • 13. Tomas M, Doumith M, Warner M, Turton JF, Beceiro A, Bou G, et al. Efflux pumps, OprD porin, AmpC beta-lactamase, and multiresistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Antimicrob Agents Chemother. 2010; 54(5): 2219-24[DOI][PubMed]
  • 14. Fazeli H, Akbari R, Moghim S, Esfahani BN. Phenotypic characterization and PCR-Ribotypic profile of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Iran. Adv Biomed Res. 2013; 2: 18[DOI][PubMed]
  • 15. Abiri R, Mohammadi P, Shavani N, Rezaei M. Detection and Genetic Characterization of Metallo-beta-Lactamase IMP-1 and VIM-2 in Pseudomonas aeruginosa Strains From Different Hospitals in Kermanshah, Iran. Jundishapur J Microbiol. 2015; 8(9)[DOI][PubMed]
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