Archives of Pediatric Infectious Diseases

Published by: Kowsar

Frequency of Candida Species Isolated from Patients in Children’s Medical Center, Tehran, Iran

Arezoo Charsizadeh 1 , Bahram Nikmanesh 2 , Bahram Ahmadi 3 , Nilufar Jalalizand 1 , Zahra Jafari 1 , Maryam Rahmani 4 , Parivash Kordbacheh 1 and Hossein Mirhendi 5 , *
Authors Information
1 Departments of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Medical Laboratory Science, School of Allied Medical Sciences, Tehran University of Medical Sciences. Tehran, Iran
3 Department of Medical Laboratory Sciences, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
4 Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
5 Departments of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Article information
  • Archives of Pediatric Infectious Diseases: January 2018, 6 (1); e62410
  • Published Online: October 3, 2017
  • Article Type: Research Article
  • Received: July 24, 2016
  • Revised: September 17, 2016
  • Accepted: October 28, 2016
  • DOI: 10.5812/pedinfect.62410

To Cite: Charsizadeh A, Nikmanesh B, Ahmadi B, Jalalizand N, Jafari Z, et al. Frequency of Candida Species Isolated from Patients in Children’s Medical Center, Tehran, Iran, Arch Pediatr Infect Dis. 2018 ; 6(1):e62410. doi: 10.5812/pedinfect.62410.

Copyright © 2017, Pediartric Infections Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Zaoutis TE, Prasad PA, Localio AR, Coffin SE, Bell LM, Walsh TJ, et al. Risk factors and predictors for candidemia in pediatric intensive care unit patients: implications for prevention. Clin Infect Dis. 2010;51(5):38-45. doi: 10.1086/655698. [PubMed: 20636126].
  • 2. Steinbach W. Pediatric invasive candidiasis: Epidemiology and diagnosis in children. J Fungal. 2016;2(1):5. doi: 10.3390/jof2010005.
  • 3. Dutta A, Zaoutis TE, Palazzi DL. An update on the epidemiology of candidemia in children. Curr Fungal Infect Rep. 2012;6(4):296-302. doi: 10.1007/s12281-012-0113-y.
  • 4. Brissaud O, Guichoux J, Harambat J, Tandonnet O, Zaoutis T. Invasive fungal disease in PICU: epidemiology and risk factors. Ann Intensive Care. 2012;2(1):6. doi: 10.1186/2110-5820-2-6. [PubMed: 22356683].
  • 5. da Silva Ruiz L, Montelli AC, Sugizaki Mde F, Da Silva EG, De Batista GC, Moreira D, et al. Outbreak of fungemia caused by Candida parapsilosis in a neonatal intensive care unit: molecular investigation through microsatellite analysis. Rev Iberoam Micol. 2013;30(2):112-5. doi: 10.1016/j.riam.2012.10.003. [PubMed: 23147512].
  • 6. Botero-Calderon L, Benjamin DJ, Cohen-Wolkowiez M. Advances in the treatment of invasive neonatal candidiasis. Expert Opin Pharmacother. 2015;16(7):1035-48. doi: 10.1517/14656566.2015.1031108. [PubMed: 25842986].
  • 7. Gammelsrud KW, Sandven P, Hoiby EA, Sandvik L, Brandtzaeg P, Gaustad P. Colonization by Candida in children with cancer, children with cystic fibrosis, and healthy controls. Clin Microbiol Infect. 2011;17(12):1875-81. doi: 10.1111/j.1469-0691.2011.03528.x. [PubMed: 21745258].
  • 8. Viale P. Candida colonization and candiduria in critically ill patients in the intensive care unit. Drugs. 2009;69 Suppl 1:51-7. doi: 10.2165/11315640-000000000-00000. [PubMed: 19877735].
  • 9. Singhi S, Deep A. Invasive candidiasis in pediatric intensive care units. Indian J Pediatr. 2009;76(10):1033-44. doi: 10.1007/s12098-009-0219-6. [PubMed: 19907936].
  • 10. Odds FC, Bernaerts R. CHROMagar Candida, a new differential isolation medium for presumptive identification of clinically important Candida species. J Clin Microbiol. 1994;32(8):1923-9. [PubMed: 7989544].
  • 11. Millar BC, Jiru X, Moore JE, Earle JAP. A simple and sensitive method to extract bacterial, yeast and fungal DNA from blood culture material. J Microbiol Methods. 2000;42(2):139-47. doi: 10.1016/s0167-7012(00)00174-3.
  • 12. Mirhendi H, Makimura K, Khoramizadeh M, Yamaguchi H. A one-enzyme PCR-RFLP assay for identification of six medically important Candida species. Nihon Ishinkin Gakkai Zasshi. 2006;47(3):225-9. [PubMed: 16940958].
  • 13. White TJ, Bruns T, Lee S, Taylor J. Amplification and direct sequencing of fungal ribosomal rna genes for phylogenetics. Mycologia. 1990;18(1):315-22. doi: 10.1016/b978-0-12-372180-8.50042-1.
  • 14. Mohammadi R, Mirhendi H, Rezaei-Matehkolaei A, Ghahri M, Shidfar MR, Jalalizand N, et al. Molecular identification and distribution profile of Candida species isolated from Iranian patients. Med Mycol. 2013;51(6):657-63. doi: 10.3109/13693786.2013.770603. [PubMed: 23470036].
  • 15. Nucci M, Queiroz-Telles F, Alvarado-Matute T, Tiraboschi IN, Cortes J, Zurita J, et al. Epidemiology of candidemia in Latin America: a laboratory-based survey. PLoS One. 2013;8(3):59373. doi: 10.1371/journal.pone.0059373. [PubMed: 23527176].
  • 16. Steinbach WJ, Roilides E, Berman D, Hoffman JA, Groll AH, Bin-Hussain I, et al. Results from a prospective, international, epidemiologic study of invasive candidiasis in children and neonates. Pediatr Infect Dis J. 2012;31(12):1252-7. doi: 10.1097/INF.0b013e3182737427. [PubMed: 22982980].
  • 17. Arslankoylu AE, Kuyucu N, Yilmaz BS, Erdogan S. Symptomatic and asymptomatic candidiasis in a pediatric intensive care unit. Ital J Pediatr. 2011;37:56. doi: 10.1186/1824-7288-37-56. [PubMed: 22104492].
  • 18. Silva S, Negri M, Henriques M, Oliveira R, Williams DW, Azeredo J. Candida glabrata, Candida parapsilosis and Candida tropicalis: biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev. 2012;36(2):288-305. doi: 10.1111/j.1574-6976.2011.00278.x. [PubMed: 21569057].
  • 19. van Asbeck EC, Clemons KV, Stevens DA. Candida parapsilosis: a review of its epidemiology, pathogenesis, clinical aspects, typing and antimicrobial susceptibility. Crit Rev Microbiol. 2009;35(4):283-309. doi: 10.3109/10408410903213393. [PubMed: 19821642].
  • 20. Taherzadeh NS, Zaini F, Daie Ghazvini R, Rezaie S, Mahmoudi M, Kadivar M. Candida colonization and species identification by two methods in NICU newborn. Tehran Univ Med J. 2016;73(11):819-26.
  • 21. Sardi J, de Souza Pitangui N, Gullo FP, e Maria AMFA, Giannini JSM. A mini review of Candida species in hospital infection: epidemiology, virulence factor and drugs resistance and prophylaxis. Trop Med Surg. 2013.
  • 22. Oliveira VK, Ruiz Lda S, Oliveira NA, Moreira D, Hahn RC, Melo AS, et al. Fungemia caused by Candida species in a children's public hospital in the city of Sao Paulo, Brazil: study in the period 2007-2010. Rev Inst Med Trop Sao Paulo. 2014;56(4):301-5. [PubMed: 25076430].
  • 23. Arendrup MC, Fisher BT, Zaoutis TE. Invasive fungal infections in the paediatric and neonatal population: diagnostics and management issues. Clin Microbiol Infect. 2009;15(7):613-24. doi: 10.1111/j.1469-0691.2009.02909.x. [PubMed: 19673972].
  • 24. Peman J, Canton E, Linares-Sicilia MJ, Rosello EM, Borrell N, Ruiz-Perez-de-Pipaon MT, et al. Epidemiology and antifungal susceptibility of bloodstream fungal isolates in pediatric patients: A spanish multicenter prospective survey. J Med Microbiol. 2011;49(12):4158-63. doi: 10.1128/jcm.05474-11.
  • 25. Storti LR, Pasquale G, Scomparim R, Galastri AL, Alterthum F, Gambale W, et al. Candida spp. isolated from inpatients, the environment, and health practitioners in the Pediatric Unit at the Universitary Hospital of the Jundiai Medical College, State of Sao Paulo, Brazil. Rev Soc Bras Med Trop. 2012;45(2):225-31. [PubMed: 22534997].
  • 26. Sobel JD, Fisher JF, Kauffman CA, Newman CA. Candida urinary tract infections--epidemiology. Clin Infect Dis. 2011;52 Suppl 6:S433-6. doi: 10.1093/cid/cir109. [PubMed: 21498836].
  • 27. Kauffman CA, Fisher JF, Sobel JD, Newman CA. Candida urinary tract infections--diagnosis. Clin Infect Dis. 2011;52 Suppl 6:S452-6. doi: 10.1093/cid/cir111. [PubMed: 21498838].
  • 28. Sousa I, Braoios A, Santos TG, Lima J, Costa R. Candiduria in adults and children: prevalence and antifungal susceptibility in outpatient of Jataí-GO. J Bras Patol Med Lab. 2014;50(4):259-64.
  • 29. Muthig M, Hebestreit A, Ziegler U, Seidler M, Muller FM. Persistence of Candida species in the respiratory tract of cystic fibrosis patients. Med Mycol. 2010;48(1):56-63. doi: 10.3109/13693780802716532. [PubMed: 19184771].
  • 30. Charles PE, Dalle F, Aube H, Doise JM, Quenot JP, Aho LS, et al. Candida spp. colonization significance in critically ill medical patients: a prospective study. Intensive Care Med. 2005;31(3):393-400. doi: 10.1007/s00134-005-2571-y. [PubMed: 15711782].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments