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A case series report of Iranian children Hemophagocytic Lymphohistiocytosis syndrome

AUTHORS

Roxana M. Ghanaie 1 , Reza Shiari 2 , Abdollah Karimi 1 , * , Shahnaz Armin 1 , Alireza Fahimzad 1 , Faride Shiva 1 , Mohammad Taghi Arzanian 3

1 Pediatric Infections Research Center, Shahid Beheshti University of Medical Sciences, dr_akarimi@yahoo.com, IR Iran

2 Department of Pediatrics, Division of Pediatric Rheumatology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, IR Iran

3 Department of Pediatrics, Division of Pediatric Oncology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, IR Iran

How to Cite: Ghanaie R, Shiari R, Karimi A, Armin S, Fahimzad A, et al. A case series report of Iranian children Hemophagocytic Lymphohistiocytosis syndrome , Arch Pediatr Infect Dis. Online ahead of Print ; 1(1):31-35. doi: 10.5812/pedinfect.4862.

ARTICLE INFORMATION

Archives of Pediatric Infectious Diseases: 1 (1); 31-35
Published Online: April 14, 2013
Article Type: Case Report
Received: March 13, 2012
Accepted: June 20, 2012
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Abstract

Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and potentially life-threatening disease and has to be considered in the differential diagnosis of many conditions. HLH comprises two different conditions that are difficult to differentiate; Familial hemophagocytic lymphohistiocytosis (FHLH) or familial erythrophagocytic lymphohistiocytosis (FEL), and Secondary hemophagocytic syndromes (secondary HLH, sHLH). Herein, we report a case series of Iranian children with HLH and describe the symptoms and outcome of this disease in Iran.

Keywords

Lymphohistiocytosis Hemophagocytic Perforin Genes

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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