Molecular Study of Respiratory Syncytial Virus, Human Rhinovirus and Human Metapneumovirus, Detected in Children With Acute Wheezing

AUTHORS

Zahra Chavoshzadeh 1 , Babak Abdinia 2 , Alireza Fahimzad 4 , * , Hamid Reza Samakosh 5 , Ghamar Tag Khanbabaei 6 , Seyed Ahmad Tabatabaei 6

1 Department of Pediatric Immunology and Allergy, Shahid Beheshti University of Medical Sciences, IR Iran

2 Department of Pediatric Infectious Diseases, Tabriz University of Medical Sciences, IR Iran

4 Department of Pediatric Infectious Diseases, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, [email protected], IR Iran

5 Department of Pediatrics, Semnan University of Medical Sciences, IR Iran

6 Department of Pediatric Pulmonology, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, IR Iran

How to Cite: Chavoshzadeh Z , Abdinia B , Fahimzad A, Samakosh H, Khanbabaei G, et al. Molecular Study of Respiratory Syncytial Virus, Human Rhinovirus and Human Metapneumovirus, Detected in Children With Acute Wheezing, Arch Pediatr Infect Dis. Online ahead of Print ; 1(1):14-17. doi: 10.5812/pedinfect.5319.

ARTICLE INFORMATION

Archives of Pediatric Infectious Diseases: 1 (1); 14-17
Published Online: April 2, 2013
Article Type: Research Article
Received: April 26, 2012
Accepted: June 20, 2012
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Abstract

Background: Viruses are known to cause the majority of acute respiratory infections. A great deal of evidence indicates that the etiology of most cases of wheezing in children, like asthma or bronchiolitis, is also linked to such respiratory infections.

Objectives: We assessed the prevalence of three common viruses including; Respiratory syncytial virus (RSV), human rhinovirus (HRV), and human Metapneumovirus (hMPV), in children with acute wheezing.

Patients and Methods: Ninety six wheezy children, 48 males (50%) and 48 females (50%)under the age of 5 years, were enrolled in the study. All patients visited as outpatients or inpatients when referred to the Mofid Children Hospital, in Tehran, from September 2009 to March 2010. A nasopharyngeal sample was taken from each childs nostril and the three viruses were detected by a molecular polymerase chain reaction method (PCR).

Results: Out of 96 patients, 63 cases (64.8%) had a positive PCR test for at least one virus. Prevalence of each virus including RSV, HRV and hMPV alone or in combination were 44 (45.8%), 13 (13.5%) and 6 (6.3%), respectively. There were no significant relationships between;age, prematurity, fever, respiratory distress and the existence of any kind of virus in the nasopharynx.

Conclusions: Our study revealed that the prevalence of these three viruses in the nasopharyngeal secretions of children suffering from acute wheezing was similar to other studies. The results of this study concluded; PCR assay is a widely available and rapid method to detect the viral etiology which induces wheezing in children in Iran, and the study also provides a baseline for future studies about the clinical importance of this relationship.

Keywords

Respiratory Tract Infections Child Respiratory Sounds Respiratory Syncytial Viruses

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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