Archives of Pediatric Infectious Diseases

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Toxocara Infection in Asthmatic Children: A Case-Control Study in Karaj District, Iran

Homa Sadri 1 , * , Mohammad Javad Gharavi 2 , Reza Arjmand 3 , Mohammad Zibaei 4 , Nasrin Elahimehr 3 and Yasaman Shaker 1
Authors Information
1 Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
2 Department of Parasitology, Alborz University of Medical Sciences, Karaj, Iran
3 Department of Pediatrics, Emam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran
4 Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
Article information
  • Archives of Pediatric Infectious Diseases: April 30, 2019, 7 (2); e82370
  • Published Online: April 17, 2019
  • Article Type: Research Article
  • Received: July 18, 2018
  • Revised: January 7, 2019
  • Accepted: March 2, 2019
  • DOI: 10.5812/pedinfect.82370

To Cite: Sadri H, Gharavi M J, Arjmand R, Zibaei M, Elahimehr N, et al. Toxocara Infection in Asthmatic Children: A Case-Control Study in Karaj District, Iran, Arch Pediatr Infect Dis. 2019 ; 7(2):e82370. doi: 10.5812/pedinfect.82370.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, et al. Global variation in the prevalence and severity of asthma symptoms: Phase three of the international study of asthma and allergies in childhood (ISAAC). Thorax. 2009;64(6):476-83. doi: 10.1136/thx.2008.106609. [PubMed: 19237391].
  • 2. Holgate ST, Sly PD. Pathogenesis. In: Adkinson NF, Bochener BS, Busse WW, Holgat ST, Lemansk FL, Estelle F, et al., editors. Middleton's allergy principle and practice. 7th ed. Mosby: Louis; 2013.
  • 3. Li L, Gao W, Yang X, Wu D, Bi H, Zhang S, et al. Asthma and toxocariasis. Ann allergy asthma immunol. 2014;113(2):187-92. doi: 10.1016/j.anai.2014.05.016. [PubMed: 24934109].
  • 4. Aghaei S, Riahi SM, Rostami A, Mohammadzadeh I, Javanian M, Tohidi E, et al. Toxocara spp. infection and risk of childhood asthma: A systematic review and meta-analysis. Acta Trop. 2018;182:298-304. doi: 10.1016/j.actatropica.2018.03.022. [PubMed: 29573999].
  • 5. Rubinsky-Elefant G, Hirata CE, Yamamoto JH, Ferreira MU. Human toxocariasis: Diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms. Ann Trop Med Parasitol. 2010;104(1):3-23. doi: 10.1179/136485910X12607012373957. [PubMed: 20149289].
  • 6. Pinelli E, Withagen C, Fonville M, Verlaan A, Dormans J, van Loveren H, et al. Persistent airway hyper-responsiveness and inflammation in Toxocara canis-infected BALB/c mice. Clin Exp Allergy. 2005;35(6):826-32. doi: 10.1111/j.1365-2222.2005.02250.x. [PubMed: 15969676].
  • 7. Buijs J, Egbers MW, Lokhorst WH, Savelkoul HF, Nijkamp FP. Toxocara-induced eosinophilic inflammation. Airway function and effect of anti-IL-5. Am J Respir Crit Care Med. 1995;151(3 Pt 1):873-8. doi: 10.1164/ajrccm.151.3.7881685. [PubMed: 7881685].
  • 8. Schantz PM. Toxocara larva migrans now. Am J Trop Med Hyg. 1989;41(3 Suppl):21-34. [PubMed: 2679161].
  • 9. Hosseini-Safa A, Mousavi SM, Bahadoran Bagh Badorani M, Ghatreh Samani M, Mostafaei S, Yousofi Darani H. Seroepidemiology of toxocariasis in children (5-15 years old) referred to the pediatric clinic of Imam Hossein Hospital, Isfahan, Iran. Iran J Parasitol. 2015;10(4):632-7. [PubMed: 26811731]. [PubMed Central: PMC4724841].
  • 10. Sadjjadi SM, Khosravi M, Mehrabani D, Orya A. Seroprevalence of toxocara infection in school children in Shiraz, southern Iran. J Trop Pediatr. 2000;46(6):327-30. doi: 10.1093/tropej/46.6.327. [PubMed: 11191141].
  • 11. Zibaei M, Sadjjadi SM. Trend of toxocariasis in Iran: A review on human and animal dimensions. Iran J Vet Res. 2017;18(4):233-42. [PubMed: 29387094]. [PubMed Central: PMC5767628].
  • 12. [No Authors Listed]. Global Initiative for Asthma (GINA). 2015. Available from:
  • 13. Takamoto M, Sugane K. Mechanisms of eosinophilia in Toxocara canis infected mice: In vitro production of interleukin 5 by lung cells of both normal and congenitally athymic nude mice. Parasite Immunol. 1993;15(9):493-500. [PubMed: 7877846].
  • 14. Buijs J, Lokhorst WH, Robinson J, Nijkamp FP. Toxocara canis-induced murine pulmonary inflammation: Analysis of cells and proteins in lung tissue and bronchoalveolar lavage fluid. Parasite Immunol. 1994;16(1):1-9. [PubMed: 8152829].
  • 15. Mosayebi M, Moini L, Hajihossein R, Didehdar M, Eslamirad Z. Detection of specific antibody reactivity to Toxocara larval excretory-secretory antigens in asthmatic patients (5-15 years). Open Microbiol J. 2016;10:162-7. doi: 10.2174/1874285801610010162. [PubMed: 27857820]. [PubMed Central: PMC5090774].
  • 16. Illi S, von Mutius E, Lau S, Niggemann B, Gruber C, Wahn U, et al. Perennial allergen sensitisation early in life and chronic asthma in children: A birth cohort study. Lancet. 2006;368(9537):763-70. doi: 10.1016/S0140-6736(06)69286-6. [PubMed: 16935687].
  • 17. Host A, Halken S. The role of allergy in childhood asthma. Allergy. 2000;55(7):600-8. [PubMed: 10921458].
  • 18. Cadore PS, Zhang L, Lemos Lde L, Lorenzi C, Telmo Pde L, Dos Santos PC, et al. Toxocariasis and childhood asthma: A case-control study. J Asthma. 2016;53(6):601-6. doi: 10.3109/02770903.2015.1064951. [PubMed: 27104477].
  • 19. Kicinski M. How does under-reporting of negative and inconclusive results affect the false-positive rate in meta-analysis? A simulation study. BMJ Open. 2014;4(8). e004831. doi: 10.1136/bmjopen-2014-004831. [PubMed: 25168036]. [PubMed Central: PMC4156818].
  • 20. Sharif M, Daryani A, Barzegar G, Nasrolahei M, Khalilian A. Seroprevalence of toxocariasis in schoolchildren in Northern Iran. Pak J Biol Sci. 2010;13(4):180-4. [PubMed: 20437685].
  • 21. Momeni T, Mahami-Oskouei M, Fallah E, Safaiyan A, Mahami-Oskouei L. Latent and asymptomatic Toxocara infection among young population in northwest Iran: The necessity of informing people as a potential health risk. Scientifica (Cairo). 2016;2016:3562056. doi: 10.1155/2016/3562056. [PubMed: 27022503]. [PubMed Central: PMC4789035].
  • 22. Nourian AA, Amiri M, Ataeian A, Haniloo A, Mosavinasab SN, Badali H. Seroepidemiological study for toxocariasis among children in Zanjan-northwest of Iran. Pak J Biol Sci. 2008;11(14):1844-7. [PubMed: 18817228].
  • 23. Dogan N, Dinleyici EC, Bor O, Toz SO, Ozbel Y. Seroepidemiological survey for Toxocara canis infection in the northwestern part of Turkey. Turkiye Parazitol Derg. 2007;31(4):288-91. [PubMed: 18224618].
  • 24. Mahmoudvand H, Taee N, Ebrahimzadeh F, Mirhosseini M, Faraji M. Seroprevalence and risk factors of Toxocara canis infection in children (2–15 years old) referred to health centers of Lorestan province, Iran. J Pediatr Infect Dis. 2018;13(1):20-4. doi: 10.1055/s-0037-1604325.
  • 25. Oliart-Guzman H, Delfino BM, Martins AC, Mantovani SA, Brana AM, Pereira TM, et al. Epidemiology and control of child toxocariasis in the western Brazilian Amazon - A population-based study. Am J Trop Med Hyg. 2014;90(4):670-81. doi: 10.4269/ajtmh.13-0506. [PubMed: 24515946]. [PubMed Central: PMC3973512].
  • 26. Garedaghi Y. Seroprevalence of toxocariasis in children in East- Azerbaijan province, Iran. Cukurova Med J. 2013;38(4):581-6. doi: 10.17826/cutf.55222.

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