Archives of Pediatric Infectious Diseases

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Hemophagocytic Lymphohistiocytosis in Children

Mohammad Saeed Sasan 1 , Forough Rakhshanizadeh 1 , * and Elahe Heidari 1
Authors Information
1 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Article information
  • Archives of Pediatric Infectious Diseases: 7 (3); e84041
  • Published Online: July 20, 2019
  • Article Type: Research Article
  • Received: September 16, 2018
  • Revised: May 17, 2019
  • Accepted: May 29, 2019
  • DOI: 10.5812/pedinfect.84041

How to Cite: Sasan M S, Rakhshanizadeh F, Heidari E. Hemophagocytic Lymphohistiocytosis in Children, Arch Pediatr Infect Dis. Online ahead of Print ; 7(3):e84041. doi: 10.5812/pedinfect.84041.

Abstract
Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Dao AT, Luong VT, Nguyen TT, Huynh QT, Phan TT, Lam MT, et al. Risk factors for early fatal outcomes among children with hemophagocytic lymphohistiocytosis (HLH): A single-institution case-series in Vietnam. Pediatr Hematol Oncol. 2014;31(3):271-81. doi: 10.3109/08880018.2013.858198. [PubMed: 24308730].
  • 2. Jordan MB, Allen CE, Weitzman S, Filipovich AH, McClain KL. How I treat hemophagocytic lymphohistiocytosis. Blood. 2011;118(15):4041-52. doi: 10.1182/blood-2011-03-278127. [PubMed: 21828139]. [PubMed Central: PMC3204727].
  • 3. Chandrakasan S, Filipovich AH. Hemophagocytic lymphohistiocytosis: Advances in pathophysiology, diagnosis, and treatment. J Pediatr. 2013;163(5):1253-9. doi: 10.1016/j.jpeds.2013.06.053. [PubMed: 23953723].
  • 4. Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48(2):124-31. doi: 10.1002/pbc.21039. [PubMed: 16937360].
  • 5. Sung L, Weitzman SS, Petric M, King SM. The role of infections in primary hemophagocytic lymphohistiocytosis: A case series and review of the literature. Clin Infect Dis. 2001;33(10):1644-8. doi: 10.1086/323675. [PubMed: 11595993].
  • 6. Ghanaie RM, Shiari R, Karimi A, Armin S, Fahimzad A, Shiva F, et al. A case series report of Iranian children Hemophagocytic Lymphohistiocytosis syndrome. Arch Pediatr Infect Dis. 2013;1(1):31-5. doi: 10.5812/pedinfect.4862.
  • 7. Arico M, Janka G, Fischer A, Henter JI, Blanche S, Elinder G, et al. Hemophagocytic lymphohistiocytosis. Report of 122 children from the International Registry. FHL Study Group of the Histiocyte Society. Leukemia. 1996;10(2):197-203. [PubMed: 8637226].
  • 8. Shamsian BS, Rezaei N, Alavi S, Hedayat M, Amin Asnafi A, Pourpak Z, et al. Primary hemophagocytic lymphohistiocytosis in Iran: Report from a single referral center. Pediatr Hematol Oncol. 2012;29(3):215-9. doi: 10.3109/08880018.2012.657338. [PubMed: 22475297].
  • 9. Rezaei N, Pourpak Z, Aghamohammadi A, Farhoudi A, Movahedi M, Gharagozlou M, et al. Consanguinity in primary immunodeficiency disorders; the report from Iranian Primary Immunodeficiency Registry. Am J Reprod Immunol. 2006;56(2):145-51. doi: 10.1111/j.1600-0897.2006.00409.x. [PubMed: 16836617].
  • 10. Leow EH, Soh SY, Tan AM, Mok YH, Chan MY, Lee JH. Critically Ill children with Hemophagocytic Lymphohistiocytosis: A case series of 14 patients. J Pediatr Hematol Oncol. 2017;39(6):e303-6. doi: 10.1097/MPH.0000000000000916. [PubMed: 28697170].
  • 11. Ramos-Casals M, Brito-Zeron P, Lopez-Guillermo A, Khamashta MA, Bosch X. Adult haemophagocytic syndrome. Lancet. 2014;383(9927):1503-16. doi: 10.1016/S0140-6736(13)61048-X. [PubMed: 24290661].
  • 12. Wang Z, Duarte AG, Schnadig VJ. Fatal reactive hemophagocytosis related to disseminated histoplasmosis with endocarditis: An unusual case diagnosed at autopsy. South Med J. 2007;100(2):208-11. doi: 10.1097/SMJ.0b013e31802b2812. [PubMed: 17330695].
  • 13. Gupta A, Weitzman S, Abdelhaleem M. The role of hemophagocytosis in bone marrow aspirates in the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008;50(2):192-4. doi: 10.1002/pbc.21441. [PubMed: 18061932].
  • 14. Allen CE, Yu X, Kozinetz CA, McClain KL. Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2008;50(6):1227-35. doi: 10.1002/pbc.21423. [PubMed: 18085676].
  • 15. Filipovich AH. Hemophagocytic lymphohistiocytosis (HLH) and related disorders. Hematology Am Soc Hematol Educ Program. 2009:127-31. doi: 10.1182/asheducation-2009.1.127. [PubMed: 20008190].
  • 16. Janka G. Hemophagocytic lymphohistiocytosis: When the immune system runs amok. Klin Padiatr. 2009;221(5):278-85. doi: 10.1055/s-0029-1237386. [PubMed: 19707989].
  • 17. Janka GE. Familial and acquired hemophagocytic lymphohistiocytosis. Annu Rev Med. 2012;63:233-46. doi: 10.1146/annurev-med-041610-134208. [PubMed: 22248322].
  • 18. Shamsian BS, Rezaei N, Alavi S, Hedayat M, Aminasnafi M, Pourpak Z, et al. Primary Hemophagocytic Lymphohistiocytosis and Hematopoeitic stem cell transplantation in Iran. Biol Blood Marrow Transplant. 2013;19(2):S306-7. doi: 10.1016/j.bbmt.2012.11.451.
  • 19. Cooper N, Rao K, Gilmour K, Hadad L, Adams S, Cale C, et al. Stem cell transplantation with reduced-intensity conditioning for hemophagocytic lymphohistiocytosis. Blood. 2006;107(3):1233-6. doi: 10.1182/blood-2005-05-1819. [PubMed: 16219800].
  • 20. Janka G, Imashuku S, Elinder G, Schneider M, Henter JI. Infection- and malignancy-associated hemophagocytic syndromes. Secondary hemophagocytic lymphohistiocytosis. Hematol Oncol Clin North Am. 1998;12(2):435-44. [PubMed: 9561911].

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